We developed the theory for the analysis of the long-span bridge wind-train-bridge (line) dynamic effect of the high-speed and speed-up railways, safety assessment methods, and a series of key technologies for wind resistance and optimization of bridge and adaptive construction control, which have been widely applied in the construction of major bridges like the Shanghai一Nantong Yangtze River Bridge for Shanghai-Nantong Railway and the Nanjing Dashengguan Yangtze River Bridge.